Cyp3a59tm1Ahs
Targeted Allele Detail
|
Symbol: |
Cyp3a59tm1Ahs |
Name: |
cytochrome P450, family 3, subfamily a, polypeptide 59; targeted mutation 1, Alfred H Schinkel |
MGI ID: |
MGI:3775600 |
Gene: |
Cyp3a59 Location: Chr5:146016067-146050097 bp, + strand Genetic Position: Chr5, 85.17 cM
|
Alliance: |
Cyp3a59tm1Ahs page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:127366
|
Parent Cell Line: |
E14 (ES Cell)
|
Strain of Origin: |
129P2/OlaHsd
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutation: |
|
Insertion
|
|
|
Mutation details: 2.2 kb downstream of exon 13 a thymidine kinase and a floxed hygromycin cassette, both in reverse transcriptional orientation, were inserted into the genomic sequence. These modifications were performed in an ES cell line in which Cyp3a57 had already been targeted.
(J:127366)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Cyp3a59 Mutation: |
44 strains or lines available
|
|
Original: |
J:127366 van Herwaarden AE, et al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J Clin Invest. 2007 Nov;117(11):3583-92 |
All: |
1 reference(s) |
|