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Cyp3a59tm1Ahs
Targeted Allele Detail
Summary
Symbol: Cyp3a59tm1Ahs
Name: cytochrome P450, family 3, subfamily a, polypeptide 59; targeted mutation 1, Alfred H Schinkel
MGI ID: MGI:3775600
Gene: Cyp3a59  Location: Chr5:146016067-146050097 bp, + strand  Genetic Position: Chr5, 85.17 cM
Alliance: Cyp3a59tm1Ahs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127366
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details2.2 kb downstream of exon 13 a thymidine kinase and a floxed hygromycin cassette, both in reverse transcriptional orientation, were inserted into the genomic sequence. These modifications were performed in an ES cell line in which Cyp3a57 had already been targeted. (J:127366)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp3a59 Mutation:  44 strains or lines available
References
Original:  J:127366 van Herwaarden AE, et al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J Clin Invest. 2007 Nov;117(11):3583-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory