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Gene trapped Allele Detail
Symbol: FlnbGt(RRF239)Byg
Name: filamin, beta; gene trap RRF239, BayGenomics
MGI ID: MGI:3775521
Synonyms: Flnb-
Gene: Flnb  Location: Chr14:7817957-7951588 bp, + strand  Genetic Position: Chr14, 4.59 cM
Mutant Cell Line:  RRF239 (BayGenomics)
Germline Transmission:  Earliest citation of germline transmission: J:132026
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     Vector Type: gene trap
Mutation detailsA BayGenomics gene trap vector was inserted into intron 3 to create an in frame 5' fusion product of exons 1-3 followed by the reporter beta-geo. The absence of the full length filamin B protein was confirmed by western blot. A beta-galactosidase assay confirmed expression of the lacZ fusion product. (J:132026)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 21 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Flnb Mutation:  105 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

Original:  J:132026 Farrington-Rock C, et al., Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome. Hum Mol Genet. 2008 Mar 1;17(5):631-41
All:  2 reference(s)

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