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Targeted Allele Detail
Symbol: Hcn4tm1Rsei
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1, Reinhart Seifert
MGI ID: MGI:3775108
Synonyms: HCN4R699Q
Gene: Hcn4  Location: Chr9:58730695-58770458 bp, + strand  Genetic Position: Chr9, 31.8 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:131820
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
Mutation detailsA floxed neo cassette and an exon 7 containing a nucleotide substitution that resulted in a glutamine for arginine amino acid substitution at position 669 (R669Q) was knocked into the open reading frame. The neo cassette was removed by subsequent germ-line cre-mediated recombination. (J:131820)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hcn4 Mutation:  38 strains or lines available
Original:  J:131820 Harzheim D, et al., Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J. 2008 Feb 20;27(4):692-703
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory