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Ptrh2tm1Eruo
Targeted Allele Detail
Nomenclature
Symbol: Ptrh2tm1Eruo
Name: peptidyl-tRNA hydrolase 2; targeted mutation 1, Erkki Ruoslahti
MGI ID: MGI:3775073
Synonyms: Bit1flxNeo
Gene: Ptrh2  Location: Chr11:86684074-86692457 bp, + strand  Genetic Position: Chr11, 51.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131853
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neo cassette with a 3' loxP site was inserted downstream of the open reading frame and an additional loxP site was inserted upstream of the open reading frame. Mice were commercially prepared by Ozgene. (J:131853)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptrh2 Mutation:  33 strains or lines available
References
Original:  J:131853 Kairouz-Wahbe R, et al., Anoikis effector Bit1 negatively regulates Erk activity. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1528-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory