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Tg(Prnp-SMN)92Ahmb
Transgene Detail
Summary
Symbol: Tg(Prnp-SMN)92Ahmb
Name: transgene insertion 92, Arthur H M Burghes
MGI ID: MGI:3774945
Synonyms: PrP92-SMN
Transgene: Tg(Prnp-SMN)92Ahmb  Location: unknown  
Alliance: Tg(Prnp-SMN)92Ahmb page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-SMN)92Ahmb expresses 1 gene
 
Mutation detailsThe PrP-SMN transgene was designed with the mouse prion protein gene (PrP or Prnp) promoter region and exon 1 and 2, full-length SMN cDNA (containing exons 1-8), and two SV40 polyA signals. Mice from founder line 92 (PrP92-SMN) were found to have 8-9 copies of the transgene. (J:131663)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
References
Original:  J:131663 Gavrilina TO, et al., Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect. Hum Mol Genet. 2008 Apr 15;17(8):1063-75
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory