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Targeted Allele Detail
Symbol: Ptprjtm1.1Weis
Name: protein tyrosine phosphatase, receptor type, J; targeted mutation 1.1, Arthur Weiss
MGI ID: MGI:3774590
Synonyms: Ptprjfloxed
Gene: Ptprj  Location: Chr2:90429754-90580647 bp, - strand  Genetic Position: Chr2, 50.19 cM, cytoband E1-2
Germline Transmission:  Earliest citation of germline transmission: J:131736
Parent Cell Line:  E14.1TG3B1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to introduce a loxP-flanked neomycin-resistance cassette in reverse transcriptional orientation to intron 17 and an additional loxP site to intron 18. Exon 18 encodes the transmembrane domain of the gene (also called CD148). The targeting construct was transfected into E14.1TG3B1 129P2/OlaHsd-derived embryonic stem (ES) cells. Targeted animals were bred with BALB/c-background CMV-Cre transgenic female mice. Progeny lacking the neomycin cassette, but retaining exon 18 flanked by loxP sites were bred to remove the CMV-Cre transgene. (J:131736)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptprj Mutation:  7 strains or lines available
Original:  J:131736 Zhu JW, et al., Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity. 2008 Feb;28(2):183-96
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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