Gt(ROSA)26Sor^{tm1(Cdkn1b,EGFP)Dor}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Cdkn1b,EGFP)Dor}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David M Ornitz
• MGI ID: MGI:3774555
• Synonyms: Rosa26^p27-eGFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Cdkn1b,EGFP)Dor} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Cdkn1b,EGFP)Dor} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cdkn1b (MGI:104565)

• Mutation details: A floxed neo cassette and a Cdkn1b-IRES-EGFP cassette were inserted into the ROSA locus. Expression of the Cdkn1b-IRES-EGFP cassette can only be induced following cre-mediated recombination to remove the neo cassette. (J:131577)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:131577 Lavine KJ, et al., Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs. Dev Dyn. 2008 Mar;237(3):713-24
• All: 3 reference(s)