Bdnf^tm1(BDNF)Yab
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1(BDNF)Yab
• Name: brain derived neurotrophic factor; targeted mutation 1, Yves-Alain Barde
• MGI ID: MGI:3774538
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1(BDNF)Yab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131394
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Exon V (the coding exon) was replaced with a human c-myc tagged version of the gene. c-Myc was added at the C-terminus of of the human gene following deletion of the last 3 amino acids. (J:131394)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 41 strains or lines available

References

• Original: J:131394 Matsumoto T, et al., Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat Neurosci. 2008 Feb;11(2):131-3
• All: 3 reference(s)