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Gene trapped Allele Detail
Symbol: Ankrd26Gt(XK525)Byg
Name: ankyrin repeat domain 26; gene trap XK525, BayGenomics
MGI ID: MGI:3774418
Gene: Ankrd26  Location: Chr6:118501308-118562226 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband F1
Ankrd26Gt(XK525)Byg/Ankrd26Gt(XK525)Byg mice (right) are extremely large and obese

Show the 2 phenotype image(s) involving this allele.

Mutant Cell Line:  XK525
Germline Transmission:  Earliest citation of germline transmission: J:130984
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped (Hypomorph)
Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     Vector Type: gene trap
Mutation detailsA beta-geo cassette was inserted into intron 24. This disrupted the formation of the coiled coil motif. Expression of a shortened fusion protein was confirmed by western blot analysis. (J:130984)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ankrd26 Mutation:  37 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
Original:  J:130984 Bera TK, et al., A model for obesity and gigantism due to disruption of the Ankrd26 gene. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):270-5
All:  5 reference(s)

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MGI 6.11
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