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Sqstm1tm1Keta
Targeted Allele Detail
Nomenclature
Symbol: Sqstm1tm1Keta
Name: sequestosome 1; targeted mutation 1, Keiji Tanaka
MGI ID: MGI:3774352
Synonyms: p62-
Gene: Sqstm1  Location: Chr11:50199366-50210827 bp, - strand  Genetic Position: Chr11, 30.36 cM, cytoband B1.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130839
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-4 were replaced with a floxed neo cassette. The absence of transcript was confirmed by northern blot analysis on brain, heart, lung, liver and kidney extracts. (J:130839)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sqstm1 Mutation:  8 strains or lines available
References
Original:  J:130839 Komatsu M, et al., Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 2007 Dec 14;131(6):1149-63
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory