Sqstm1^tm1Keta
Targeted Allele Detail

Summary

• Symbol: Sqstm1^tm1Keta
• Name: sequestosome 1; targeted mutation 1, Keiji Tanaka
• MGI ID: MGI:3774352
• Synonyms: p62^-
• Gene: Sqstm1 Location: Chr11:50090193-50101654 bp, - strand Genetic Position: Chr11, 30.36 cM, cytoband B1.2
• Alliance: Sqstm1^tm1Keta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130839
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-4 were replaced with a floxed neo cassette. The absence of transcript was confirmed by northern blot analysis on brain, heart, lung, liver and kidney extracts. (J:130839)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sqstm1 Mutation: 32 strains or lines available

References

• Original: J:130839 Komatsu M, et al., Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 2007 Dec 14;131(6):1149-63
• All: 49 reference(s)