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Otx2tm3Tlam
Targeted Allele Detail
Summary
Symbol: Otx2tm3Tlam
Name: orthodenticle homeobox 2; targeted mutation 3, Thomas Lamonerie
MGI ID: MGI:3774322
Synonyms: Otx2OG, Otx2Otx2-GFP
Gene: Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance: Otx2tm3Tlam page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130649
Parent Cell Line:  ENS (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Hypomorph, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette containing a GFP and frt-flanked neo cassette was inserted after the last coding region. The neo cassette was removed by flp-mediated recombination. Expression of the GFP fusion was confirmed by western blot analysis on E9.5 tail and head extracts. Authors state that this allele is hypomorphic. (J:130649)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 69 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  50 strains or lines available
References
Original:  J:130649 Fossat N, et al., A new GFP-tagged line reveals unexpected Otx2 protein localization in retinal photoreceptors. BMC Dev Biol. 2007;7:122
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory