Ffar1^tm1Heed
Targeted Allele Detail

Summary

• Symbol: Ffar1^tm1Heed
• Name: free fatty acid receptor 1; targeted mutation 1, Helena Edlund
• MGI ID: MGI:3774293
• Synonyms: Gpr40^-
• Gene: Ffar1 Location: Chr7:30559993-30560895 bp, - strand Genetic Position: Chr7, 19.25 cM
• Alliance: Ffar1^tm1Heed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129843
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire open reading frame was replaced with an IRES-nlslacZ, an SV40 polyadenylation signal and a floxed neo cassette. The absence of transcript was confirmed by in situ hybridization. This is a null allele. (J:129843)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ffar1 Mutation: 17 strains or lines available

References

• Original: J:129843 Steneberg P, et al., The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab. 2005 Apr;1(4):245-58
• All: 5 reference(s)