About   Help   FAQ
Nr1h4tm1.1Gonz
Targeted Allele Detail
Nomenclature
Symbol: Nr1h4tm1.1Gonz
Name: nuclear receptor subfamily 1, group H, member 4; targeted mutation 1.1, Frank Gonzalez
MGI ID: MGI:3774280
Synonyms: Fxrfl
Gene: Nr1h4  Location: Chr10:89290096-89369447 bp, - strand  Genetic Position: Chr10, 44.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64792
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted in the intron 5' to the last exon and a loxP-flanked neomycin cassette was inserted 3' to the last exon. (J:64792)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1h4 Mutation:  27 strains or lines available
References
Original:  J:64792 Sinal CJ, et al., Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 2000 Sep 15;102(6):731-44
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/30/2021
MGI 6.17
The Jackson Laboratory