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Cd4tm1Yzo
Targeted Allele Detail
Nomenclature
Symbol: Cd4tm1Yzo
Name: CD4 antigen; targeted mutation 1, Yong-Rui Zou
MGI ID: MGI:3774141
Synonyms: Cd4S4FL, Cd4Sflox, silflox
Gene: Cd4  Location: Chr6:124864692-124888221 bp, - strand  Genetic Position: Chr6, 59.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130559
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, Modified regulatory region, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted upstream of the intronic silencer and an additional loxP site was inserted downstream of the silencer. Cre-mediated recombination was used to remove the neo cassette. (J:130559)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd4 Mutation:  65 strains or lines available
References
Original:  J:130559 Zou YR, et al., Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat Genet. 2001 Nov;29(3):332-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory