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Targeted Allele Detail
Symbol: Slc4a10tm1.1Cahb
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10; targeted mutation 1.1, Christian Hubner
MGI ID: MGI:3774019
Synonyms: Ncbe/Nbcn2-ko
Gene: Slc4a10  Location: Chr2:62046462-62326730 bp, + strand  Genetic Position: Chr2, 35.79 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:131058
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was inserted 3' to exon 12 and an additional loxP site was inserted 5' to exon 12. Transient cre expression resulted in the excision of the neo cassette and exon 12. The absence of protein product was confirmed by western blot analysis on brain extracts and immunohistochemistry on the brain. (J:131058)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc4a10 Mutation:  52 strains or lines available
Original:  J:131058 Jacobs S, et al., Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):311-6
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory