Rr381^tm2.1Tani
Targeted Allele Detail

Summary

• Symbol: Rr381^tm2.1Tani
• Name: regulatory region 381; targeted mutation 2.1, Ichiro Taniuchi
• MGI ID: MGI:3774006
• Synonyms: Th-POK^GFP:Sdelta
• Gene: Rr381 Location: Chr3:89303454-89303824 bp Genetic Position: Chr3, Syntenic
• Alliance: Rr381^tm2.1Tani page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131081
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Zbtb7b silencer (RBS-1) was deleted in the Zbtb7b^tm1Tani allele (where the Zbtb7b coding region was replaced with GFP and a loxP site flanked neomycin resistance gene cassette) carried by the ES cells. The neo cassette was removed through subsequent Cre-mediated recombination. (J:131081)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr381 Mutation: 0 strains or lines available

References

• Original: J:131081 Setoguchi R, et al., Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science. 2008 Feb 8;319(5864):822-5
• All: 1 reference(s)