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Tcra/Tcrdtm1.1(Tcra)Rsky
Targeted Allele Detail
Nomenclature
Symbol: Tcra/Tcrdtm1.1(Tcra)Rsky
Name: T cell receptor alpha chain; targeted mutation 1.1, Klaus Rajewsky
MGI ID: MGI:3773839
Synonyms: HYalphaIdelta
Gene: Tcra  Location: Chr14:52427967-54224198 bp, + strand  Genetic Position: Chr14, cytoband D1-D2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81564
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsMice carrying the Tcratm1(Tcra)Rsky allele were crossed with a Cre deleter strain to remove the Tcrd locus and allow expression of the knocked in Tcra. This Tcra partly encodes for a T cell receptor that recognizes the HY male antigen. (J:81564)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcra Mutation:  89 strains or lines available
References
Original:  J:81564 Buch T, et al., Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity. 2002 May;16(5):707-18
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory