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Transgene Detail
Symbol: Tg(Tcra,Tcrb)HRVAll
Name: transgene insertion HRV, James P Allison
MGI ID: MGI:3773740
Synonyms: HRV TCR
Transgene: Tg(Tcra,Tcrb)HRVAll  Location: unknown  
Strain of Origin:  either: C57BL/6 or (CBA x C57BL/6)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Tcra,Tcrb)HRVAll expresses 2 genes
Mutation detailsRearranged Valpha2-SGTGGYKV TCRalpha and Vbeta8.3-SGTGGSAETL TCRbeta chains were cloned from a population of CD8+ T cells that recognizes a 17-mer peptide from the C-terminus of Histone 4 family members presented on H2-Kb. The recombined gene segments were placed in a TCR expression vector and injected into blastocytes. This founder line is characterized by "variegated" expression of the transgenic TCR with about 28% of CD8+ T cells expressing the transgenic TCR. (J:131347)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:131347 Savage PA, et al., Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes. Science. 2008 Jan 11;319(5860):215-20
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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