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Toxtm1.1Kay
Targeted Allele Detail
Nomenclature
Symbol: Toxtm1.1Kay
Name: thymocyte selection-associated high mobility group box; targeted mutation 1.1, Jonathan Kaye
MGI ID: MGI:3773716
Gene: Tox  Location: Chr4:6686353-6991557 bp, - strand  Genetic Position: Chr4, 3.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131287
Parent Cell Line:  CMTI-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Transient expression of cre recombinase removed the neo cassette and exon 1. The absence of protein product was confirmed by western blot analysis on total thymocyte extracts. (J:131287)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tox Mutation:  3 strains or lines available
References
Original:  J:131287 Aliahmad P, et al., Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med. 2008 Jan 21;205(1):245-56
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory