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Targeted Allele Detail
Symbol: Traf6tm2Ywc
Name: TNF receptor-associated factor 6; targeted mutation 2, Yongwon Choi
MGI ID: MGI:3773273
Synonyms: Traf6floxed
Gene: Traf6  Location: Chr2:101678429-101701669 bp, + strand  Genetic Position: Chr2, 53.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:85808
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neomycin selection cassette was placed upstream of exon 7 and a STOP cassette followed by a loxP site and an YFP reporter were placed downstream of exon 7. Cre expression will remove the neo cassette, exon 7, and the stop sequence so that Traf6 expression is replaced with YFP expression. (J:85808)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf6 Mutation:  9 strains or lines available
Original:  J:85808 Kobayashi T, et al., TRAF6 is a critical factor for dendritic cell maturation and development. Immunity. 2003 Sep;19(3):353-63
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory