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Mavstm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Mavstm1Aki
Name: mitochondrial antiviral signaling protein; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3773161
Synonyms: IPS-1-
Gene: Mavs  Location: Chr2:131234063-131248025 bp, + strand  Genetic Position: Chr2, 63.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124405
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:124405)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mavs Mutation:  22 strains or lines available
References
Original:  J:124405 Kumar H, et al., Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med. 2006 Jul 10;203(7):1795-803
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory