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Kcnq1ot1tm1Tilg
Targeted Allele Detail
Nomenclature
Symbol: Kcnq1ot1tm1Tilg
Name: KCNQ1 overlapping transcript 1; targeted mutation 1, Shirley M Tilghman
MGI ID: MGI:3773017
Synonyms: DMRdelta, KvDMR-
Gene: Kcnq1ot1  Location: Chr7:143212155-143296549 bp, - strand  Genetic Position: Chr7, 88.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108700
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced the CpG island, three DNAse hypersensitive sites in the promoter of the gene, and five repeat sequences that lie within the transcript of the gene. After recombination and generation of chimeric mice, Cre was transiently expressed to remove the neomycin cassette, leaving a single loxP site behind. Heterozygous mice that inherit the deletion paternally do not express the gene transcript as determined by RNAse protection assay. (J:108700)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnq1ot1 Mutation:  0 strains or lines available
References
Original:  J:108700 Mancini-Dinardo D, et al., Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Genes Dev. 2006 May 15;20(10):1268-82
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory