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Transgene Detail
Symbol: Tg(tetO-Mcpt1)1Mrab
Name: transgene insertion 1, Marlene Rabinovitch
MGI ID: MGI:3772577
Synonyms: RVCH+, TRE-RVCH-HA
Transgene: Tg(tetO-Mcpt1)1Mrab  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Mutation:    Insertion
Tg(tetO-Mcpt1)1Mrab expresses 1 gene
Mutation detailsThe transgene was designed with the tetracycline-responsive element (TRE; also called tet-operator or tetO) upstream of a rat vascular chymase (RVCH or Mcpt1) gene modified such that a human influenza hemagglutinin (HA) tag is added to the C terminus of mature RVCH protein. With addition of dox expression of the RVCH-HA fusion protein can be completely abolished, reversing the hypertension phenotype. (J:70031)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:70031 Ju H, et al., Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7469-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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