Apom^tm1Cchr
Targeted Allele Detail

Summary

• Symbol: Apom^tm1Cchr
• Name: apolipoprotein M; targeted mutation 1, Christina Christoffersen
• MGI ID: MGI:3772574
• Synonyms: ApoM^-
• Gene: Apom Location: Chr17:35347973-35350777 bp, - strand Genetic Position: Chr17, 18.59 cM, cytoband B2
• Alliance: Apom^tm1Cchr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130647
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette was inserted into exon 2 deleting 39 bp of endogenous sequence. The absence of protein expression was confirmed by western blot analysis on serum. (J:130647)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apom Mutation: 9 strains or lines available

References

• Original: J:130647 Christoffersen C, et al., Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice. J Biol Chem. 2008 Jan 25;283(4):1839-47
• All: 14 reference(s)