Orai1^Gt(XL922)Byg
Gene trapped Allele Detail

Summary

• Symbol: Orai1^Gt(XL922)Byg
• Name: ORAI calcium release-activated calcium modulator 1; gene trap XL922, BayGenomics
• MGI ID: MGI:3772453
• Synonyms: CRACM1^-, Orai1^-
• Gene: Orai1 Location: Chr5:123153137-123168519 bp, + strand Genetic Position: Chr5, 62.72 cM
• Alliance: Orai1^Gt(XL922)Byg page

Mutation origin

• Mutant Cell Line: XL922
• Germline Transmission: Earliest citation of germline transmission: J:130479
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: A gene trap vector containing the beta-geo cassette was inserted into intron 1. Authors state that this is a null allele. (J:130479)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XL922	CC325168 ; (MGI Seq Detail)	5' RACE	Chr5:123153439-123153627 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  22 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Orai1 Mutation: 21 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:130479 Vig M, et al., Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol. 2008 Jan;9(1):89-96
• All: 17 reference(s)