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Polr2atm1(cre/ERT2)Bbd
Targeted Allele Detail
Nomenclature
Symbol: Polr2atm1(cre/ERT2)Bbd
Name: polymerase (RNA) II (DNA directed) polypeptide A; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:3772332
Synonyms: Polr2atm1(cre/ESR1)Bbd, RERT, RERTert, RERTn, RERTnert, RNAPII(CreERT2)
Gene: Polr2a  Location: Chr11:69624823-69649459 bp, - strand  Genetic Position: Chr11, 42.86 cM, cytoband B1-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86101
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsAn IRES-cre/ERT2 cassette was knocked in between the termination codon and the polyadenylation signal to allow for biscistronic inducible expression of cre. (J:98944)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Polr2a     Summary of all recombinase alleles driven by Polr2a.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Polr2a Mutation:  52 strains or lines available
References
Original:  J:86101 Guerra C, et al., Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell. 2003 Aug;4(2):111-20
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory