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Cldn6tm1(cre/ERT2)Dam
Targeted Allele Detail
Nomenclature
Symbol: Cldn6tm1(cre/ERT2)Dam
Name: claudin 6; targeted mutation 1, Douglas A Melton
MGI ID: MGI:3772092
Synonyms: Cldn6CIHV, Cldn6tm1(cre/ESR1)Dam
Gene: Cldn6  Location: Chr17:23898321-23901420 bp, + strand  Genetic Position: Chr17, 11.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130142
Parent Cell Line:  AV3 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire reading frame contained within exon 3 was replaced with the CIHV cassette that contains cre-ER, IRES, HIST2H2BE-Venus and a self-excising neo cassette. The absence of transcript was confirmed by in situ hybridization. This allele also functions as a reporter. (J:130142)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cldn6     Summary of all recombinase alleles driven by Cldn6. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cldn6 Mutation:  14 strains or lines available
References
Original:  J:130142 Anderson WJ, et al., Genetic targeting of the endoderm with claudin-6(CreER). Dev Dyn. 2008 Feb;237(2):504-12
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory