Cldn6tm1(cre/ERT2)Dam
Targeted Allele Detail
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Symbol: |
Cldn6tm1(cre/ERT2)Dam |
Name: |
claudin 6; targeted mutation 1, Douglas A Melton |
MGI ID: |
MGI:3772092 |
Synonyms: |
Cldn6CIHV, Cldn6tm1(cre/ESR1)Dam |
Gene: |
Cldn6 Location: Chr17:23898345-23901417 bp, + strand Genetic Position: Chr17, 11.99 cM
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Alliance: |
Cldn6tm1(cre/ERT2)Dam page
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Germline Transmission: |
Earliest citation of germline transmission:
J:130142
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Parent Cell Line: |
AV3 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Cldn6tm1(cre/ERT2)Dam expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The entire reading frame contained within exon 3 was replaced with the CIHV cassette that contains cre-ER, IRES, HIST2H2BE-Venus and a self-excising neo cassette. The absence of transcript was confirmed by in situ hybridization. This allele also functions as a reporter.
(J:130142)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Cldn6
(mouse)
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Original: |
J:130142 Anderson WJ, et al., Genetic targeting of the endoderm with claudin-6(CreER). Dev Dyn. 2008 Feb;237(2):504-12 |
All: |
3 reference(s) |
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