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Targeted Allele Detail
Symbol: Bcamtm1Ics
Name: basal cell adhesion molecule; targeted mutation 1, Mouse Clinical Institute
MGI ID: MGI:3771876
Synonyms: Lu-
Gene: Bcam  Location: Chr7:19756131-19771016 bp, - strand  Genetic Position: Chr7, 9.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:130191
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Duplication, Insertion
  Bcamtm1Ics involves 1 genes/genome features (Bcam) View all
Mutation detailsA cassette containing the Agouti, 3'hprt and puro genes was inserted into intron 8 and resulted in a duplication of exons 2 through 8. The absence of protein product was confirmed by western blot analysis on kidney and intestine extracts. (J:130191)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcam Mutation:  17 strains or lines available
Insertion results in duplication of exons 2 through 8.
Original:  J:130191 Rahuel C, et al., Genetic inactivation of the laminin {alpha}5 chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse. Am J Physiol Renal Physiol. 2008 Feb;294(2):F393-406
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory