Slc40a1^tm2Nca
Targeted Allele Detail

Summary

• Symbol: Slc40a1^tm2Nca
• Name: solute carrier family 40 (iron-regulated transporter), member 1; targeted mutation 2, Nancy C Andrews
• MGI ID: MGI:3771548
• Synonyms: Ferroportin^flox, Fpn^flox
• Gene: Slc40a1 Location: Chr1:45947228-45965683 bp, - strand Genetic Position: Chr1, 23.96 cM, cytoband B
• Alliance: Slc40a1^tm2Nca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129846
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo-cassette was inserted in intron 5 and a third loxP site was inserted in intron 7 via homologous recombination. The floxed neo cassette was removed by in vivo cre-mediated recombination leaving exons 6 and 7 flanked by loxP sites. (J:129846)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc40a1 Mutation: 53 strains or lines available

References

• Original: J:129846 Donovan A, et al., The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005 Mar;1(3):191-200
• All: 25 reference(s)