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Targeted Allele Detail
Symbol: Slc40a1tm2Nca
Name: solute carrier family 40 (iron-regulated transporter), member 1; targeted mutation 2, Nancy C Andrews
MGI ID: MGI:3771548
Synonyms: Ferroportinflox, Fpnflox
Gene: Slc40a1  Location: Chr1:45947228-45965683 bp, - strand  Genetic Position: Chr1, 23.96 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:129846
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo-cassette was inserted in intron 5 and a third loxP site was inserted in intron 7 via homologous recombination. The floxed neo cassette was removed by in vivo cre-mediated recombination leaving exons 6 and 7 flanked by loxP sites. (J:129846)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc40a1 Mutation:  31 strains or lines available
Original:  J:129846 Donovan A, et al., The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005 Mar;1(3):191-200
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory