Siglecg^tm1Yliu
Targeted Allele Detail

Summary

• Symbol: Siglecg^tm1Yliu
• Name: sialic acid binding Ig-like lectin G; targeted mutation 1, Yang Liu
• MGI ID: MGI:3771358
• Gene: Siglecg Location: Chr7:43057623-43067773 bp, + strand Genetic Position: Chr7, 28.25 cM
• Alliance: Siglecg^tm1Yliu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130017
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A GFP cassette and a neomycin resistance cassette that is flanked by both loxP and FRT sites was inserted upstream of the ATG site of exon 2. The cassette replaces about 5kb of sequence, including exons 3 through 11. GFP expression was detected hematopoetic cell types with highest expression in B cells. (J:130017)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Siglecg Mutation: 41 strains or lines available

References

• Original: J:130017 Ding C, et al., Siglecg Limits the Size of B1a B Cell Lineage by Down-Regulating NFkappaB Activation. PLoS One. 2007;2(10):e997
• All: 8 reference(s)