About   Help   FAQ
Fwth2C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Fwth2C57BL/6J
Name: facial width 2; C57BL/6J
MGI ID: MGI:3771341
QTL: Fwth2  Location: unknown  Genetic Position: Chr13, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:85782

Linkage analysis was performed on 110 animals from a (C57BL/6J x DBA/2J)F2 intercross to identify QTLs associated with craniofacial traits such as snout length and face width. Parental strain DBA/2J displays shorter snouts and wider faces compared to parental strain C57BL/6J.

Significant linkage to snout length mapped to 44 cM on mouse Chromosome 12 near D12Mit7 with LOD=5.2. This locus is named Ssnt1 (short snout 1). Homozygosity for C57BL/6J-derived alleles at Ssnt1 appears to confer shorter snout length compared to homozygosity for DBA/2J-derived alleles at Ssnt1.

Ssnt2 (short snout 2) mapped to 64 cM on mouse Chromosome 6 near D6Mit200 (LOD=4.3). Homozygosity for C57BL/6J-derived alleles at Ssnt2 confers shorter snout length compared to DBA/2J homozygotes.

Ssnt3 mapped to 0 cM on mouse Chromosome 18 near D18Mit4 (LOD=4.7). Homozygosity for DBA/2J-derived alleles at Ssnt3 confers decreased snout length compared to homozygosity for C57BL/6J-derived alleles.

Linkage to facial width mapped to 60 cMon mouse Chromosome 10 near D10Mit162 (LOD=3). This locus is named Fwth1 (facial width 1). Homozygosity for C57BL/6J-derived alleles at this locus confers wider facial measurements compared to homozygosity for DBA/2J-derived alleles.

Fwth2 (facial width 2) mapped to 58 cM on mouse Chromosome 13 near D13Mit139 (LOD=3.5). Homozygosity for DBA/2J-derived alleles at Fwth2 confers increased face width compared to homozygosity for C57BL/6J-derived alleles.

References
Original:  J:85782 Nishimura I, et al., Enu large-scale mutagenesis and quantitative trait linkage (qtl) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities. Crit Rev Oral Biol Med. 2003;14(5):320-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/16/2021
MGI 6.16
The Jackson Laboratory