Tg(Myh6-NFKBIA*S32A*S36A)17Kykj
Transgene Detail

Summary

• Symbol: Tg(Myh6-NFKBIA*S32A*S36A)17Kykj
• Name: transgene insertion 17, W Keith Jones
• MGI ID: MGI:3771152
• Synonyms: 2M, TgN(IKBABD)17-Kykj
• Transgene: Tg(Myh6-NFKBIA*S32A*S36A)17Kykj Location: unknown
• Alliance: Tg(Myh6-NFKBIA*S32A*S36A)17Kykj page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-NFKBIA*S32A*S36A)17Kykj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NFKBIA (4792)

  Nfkbia

  (MGI:104741)

  Transgene codes for a protein with two serine to alanine mutations.

• Mutation details: The 1.1 kb human NFKBIA cDNA with two introduced point mutations at codons 32 and 36 (resulting in amino acid changes S32A and S36A) was subcloned between the 5.5 kb alpha-myosin heavy chain promoter and the 736 bp human growth hormone (Hgh) polyadenylation signal. Five founders with 1, 2 (line 17), 7 (line 44), 4 (line 151), and 7 (line 159) copies of the transgene were identified, but no offspring from the single copy number founder were obtained. (J:102613)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:102613 Dawn B, et al., Cardiac-specific abrogation of NF- kappa B activation in mice by transdominant expression of a mutant I kappa B alpha. J Mol Cell Cardiol. 2001 Jan;33(1):161-73
• All: 7 reference(s)