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Targeted Allele Detail
Symbol: Nbntm2.1Jpt
Name: nibrin; targeted mutation 2.1, John H Petrini
MGI ID: MGI:3771078
Synonyms: Nbs1deltaC
Gene: Nbn  Location: Chr4:15957925-15992589 bp, + strand  Genetic Position: Chr4, 6.66 cM, cytoband A
Germline Transmission:  Earliest citation of germline transmission: J:129762
Parent Cell Line:  AC1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA floxed neo cassette was inserted into intron 14 and additional loxP site was inserted into intron 15. Cre mediated recombination was used to remove the neo cassette and exon 15. The protein product lacks the last 24 amino acids that contains the ATM binding domain. The presence of a shortened protein product was confirmed by western blot analysis on extracts from mouse embryonic fibroblasts. (J:129762)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nbn Mutation:  38 strains or lines available
Original:  J:129762 Stracker TH, et al., The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature. 2007 May 10;447(7141):218-21
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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