About   Help   FAQ
Nbntm2.1Jpt
Targeted Allele Detail
Summary
Symbol: Nbntm2.1Jpt
Name: nibrin; targeted mutation 2.1, John H Petrini
MGI ID: MGI:3771078
Synonyms: Nbs1deltaC
Gene: Nbn  Location: Chr4:15957925-15992589 bp, + strand  Genetic Position: Chr4, 6.66 cM, cytoband A
Alliance: Nbntm2.1Jpt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129762
Parent Cell Line:  AC1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA floxed neo cassette was inserted into intron 14 and additional loxP site was inserted into intron 15. Cre mediated recombination was used to remove the neo cassette and exon 15. The protein product lacks the last 24 amino acids that contains the ATM binding domain. The presence of a shortened protein product was confirmed by western blot analysis on extracts from mouse embryonic fibroblasts. (J:129762)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Nbntm2.1Jpt
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nbn Mutation:  59 strains or lines available
References
Original:  J:129762 Stracker TH, et al., The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature. 2007 May 10;447(7141):218-21
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory