Tg(CMV-Atp2a2)CJ5Whd
Transgene Detail

Summary

• Symbol: Tg(CMV-Atp2a2)CJ5Whd
• Name: transgene insertion CJ5, Wolfgang H Dillmann
• MGI ID: MGI:3771074
• Transgene: Tg(CMV-Atp2a2)CJ5Whd Location: unknown
• Alliance: Tg(CMV-Atp2a2)CJ5Whd page

Transgene origin

• Strain of Origin: BALB/c x C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-Atp2a2)CJ5Whd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Atp2a2 (29693)

  Atp2a2

  (MGI:88110)

• Mutation details: This transgene expresses a rat Atp2a2 cDNA under the control of a human cytomegalovirus immediate early enhancer linked to the chicken beta-actin minimal promoter. The transgene copy number is estimated to be 2, and the total amount of expressed RNA in heart ventricles is 2.6-fold higher than in control littermates. An additional transgenic line from founder CJ2 was also established. (J:107873)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:107873 He H, et al., Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. J Clin Invest. 1997 Jul 15;100(2):380-9
• All: 6 reference(s)