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Casp14tm1Wdec
Targeted Allele Detail
Nomenclature
Symbol: Casp14tm1Wdec
Name: caspase 14; targeted mutation 1, Wim Declercq
MGI ID: MGI:3770173
Synonyms: Casp14-, caspase-14-
Gene: Casp14  Location: Chr10:78711991-78718294 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129490
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4 were replaced with a neo cassette to create a null allele. The absence of protein product was confirmed by western blot analysis. (J:129490)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp14 Mutation:  6 strains or lines available
References
Original:  J:129490 Denecker G, et al., Caspase-14 protects against epidermal UVB photodamage and water loss. Nat Cell Biol. 2007 Jun;9(6):666-74
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory