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Chemically induced Allele Detail
Symbol: Col1a1Aga2
Name: collagen, type I, alpha 1; abnormal gait 2
MGI ID: MGI:3769585
Synonyms: Aga2, Aga2mild, Aga2severe
Gene: Col1a1  Location: Chr11:94936224-94953042 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Col1a1Aga2/Col1a+ mice display skeletal and growth abnormalities

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  C3HeB/FeJ
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThis mutation was identified in the Munich ENU dominant mutagenesis screen. A T to A transverion was identified within intron 50, generating a novel 3' splice acceptor site. The mutation results in a 16 base expansion of the transcript. (J:129569)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  68 strains or lines available
Original:  J:129569 Lisse TS, et al., ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. PLoS Genet. 2008 Feb;4(2):e7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory