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Targeted Allele Detail
Symbol: Arhgef1tm1Djle
Name: Rho guanine nucleotide exchange factor (GEF) 1; targeted mutation 1, David J Lerner
MGI ID: MGI:3769502
Synonyms: Lsc-
Gene: Arhgef1  Location: Chr7:24902912-24926594 bp, + strand  Genetic Position: Chr7, 13.52 cM
Germline Transmission:  Earliest citation of germline transmission: J:129331
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details1370 nucleaotide upstream of the start codon through the first 13 exons was replaced with a neo cassette eliminating the first 420 amino acids of the protein. The absence of protein was confirmed by western blot analysis on splenocyte and neutrophil extracts. (J:129331)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef1 Mutation:  53 strains or lines available
Original:  J:129331 Francis SA, et al., Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood. 2006 Feb 15;107(4):1627-35
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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