Tg(Ckm-Pah)15Mes
Transgene Detail

Summary

• Symbol: Tg(Ckm-Pah)15Mes
• Name: transgene insertion 15, Albee Messing
• MGI ID: MGI:3769421
• Synonyms: Tg(Mck-Pah)15Mes, TgN(MCKPah)15Mes
• Transgene: Tg(Ckm-Pah)15Mes Location: unknown
• Alliance: Tg(Ckm-Pah)15Mes page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-Pah)15Mes expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pah (MGI:97473)

• Mutation details: Mouse liver Pah cDNA was fused to a 3300 bp DNA sequence from the 5' regulatory regions of the mouse muscle creatine kinase (MCK) gene. This line carries approximately 5-10 copies of the transgene as a tandem repeat. PAH activity was detected in tissue homogenates from liver and kidney and also in both skeletal and cardiac muscle. (J:47853)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:47853 Harding CO, et al., Metabolic engineering as therapy for inborn errors of metabolism--development of mice with phenylalanine hydroxylase expression in muscle. Gene Ther. 1998 May;5(5):677-83
• All: 1 reference(s)