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Gjb5tm1Kwi
Targeted Allele Detail
Summary
Symbol: Gjb5tm1Kwi
Name: gap junction protein, beta 5; targeted mutation 1, Klaus Willecke
MGI ID: MGI:3769388
Synonyms: Cx31.1-
Gene: Gjb5  Location: Chr4:127248600-127251957 bp, - strand  Genetic Position: Chr4, 61.51 cM
Alliance: Gjb5tm1Kwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128922
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame was replaced with a promoterless lacZ gene with a nuclear localization signal and a floxed PGK-hprt cassette that was subsequently removed by cre-mediated recombination. The absence of transcript was confirmed by northern blot analysis on placenta and skin extracts. (J:128922)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 52 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjb5 Mutation:  19 strains or lines available
References
Original:  J:128922 Zheng-Fischhofer Q, et al., Characterization of connexin31.1-deficient mice reveals impaired placental development. Dev Biol. 2007 Dec 1;312(1):258-71
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory