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Smad9tm1Jfm
Targeted Allele Detail
Nomenclature
Symbol: Smad9tm1Jfm
Name: SMAD family member 9; targeted mutation 1, James F Martin
MGI ID: MGI:3769363
Synonyms: Smad8ex4,5
Gene: Smad9  Location: Chr3:54755582-54801257 bp, + strand  Genetic Position: Chr3, 25.62 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128934
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 4 and a loxP site and frt flanked neo cassette were inserted downstream of exon 4 via homologous recombination. Cre mediated recombination deleted exons 4 and 5, which encode most of the MH2 domain, leaving a single loxP site and the frt flanked neo cassette. (J:128934, J:150213)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad9 Mutation:  14 strains or lines available
References
Original:  J:128934 Pangas SA, et al., Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol Cell Biol. 2008 Jan;28(1):248-57
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory