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Targeted Allele Detail
Symbol: Frs2tm1.1Fwan
Name: fibroblast growth factor receptor substrate 2; targeted mutation 1.1, Fen Wang
MGI ID: MGI:3768913
Synonyms: Frs2alphanullneo
Gene: Frs2  Location: Chr10:117070127-117148474 bp, - strand  Genetic Position: Chr10, 65.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:128712
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsFrs2tm1Fwan mice were crossed with Cre knockin mice to generate a null allele in the germline. A truncated gene transcript was confirmed by RNAse protection assay on heterozygote kidney extracts. Heterozygotes were indistinguishabe from wild-type mice, suggesting that the truncated transcript did not encode for a dominant-negative protein. (J:128712)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Frs2 Mutation:  57 strains or lines available
Original:  J:128712 Lin Y, et al., Generation of an Frs2alpha conditional null allele. Genesis. 2007 Sep;45(9):554-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory