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Tgfb3tm1(cre)Vk
Targeted Allele Detail
Nomenclature
Symbol: Tgfb3tm1(cre)Vk
Name: transforming growth factor, beta 3; targeted mutation 1, Vesa Kaartinen
MGI ID: MGI:3768673
Synonyms: Tgfb3-Cre
Gene: Tgfb3  Location: Chr12:86056745-86079041 bp, - strand  Genetic Position: Chr12, 40.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128938
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA promoterless Cre gene and a neomycin-resistant gene replaced the start site within exon 1. Cre expression was detected in the prefusion palatal epithelium. (J:128938)
Recombinase
activity
Activity:
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Driver: Tgfb3     Summary of all recombinase alleles driven by Tgfb3. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfb3 Mutation:  31 strains or lines available
References
Original:  J:128938 Yang LT, et al., Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants. Dev Biol. 2007 Dec 1;312(1):384-95
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory