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Transgene Detail
Symbol: Tg(Thy1-MAPT*P301L)2Vln
Name: transgene insertion 2, Fred Van Leuven
MGI ID: MGI:3768525
Synonyms: tau-4R/2N-P301L, Tau.P301L
Transgene: Tg(Thy1-MAPT*P301L)2Vln  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-MAPT*P301L)2Vln expresses 1 gene
Mutation detailsA human MAPT cDNA encoding the longest tau isoform of 441 amino acids containing four repeats, with 2 N-terminal inserts, and also carrying an engineered mutation to alter codon 301 from one encoding proline to encoding leucine, was inserted into a murine Thy1 expression vector. Expression of the mutant human tau (MAPT*P301L) protein was detected in layers II, V and VI of the neocortex, in layer III of the entorhinal cortex, in thd basolateral amygdala, hippocampus, zona incerta of the thalamus, brain stem nuclei and spinal cord. (J:96869)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:96869 Terwel D, et al., Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. J Biol Chem. 2005 Feb 4;280(5):3963-73
All:  12 reference(s)

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MGI 6.01
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