Tg(GFAP-APOE_i4)1Vln
Transgene Detail

Summary

• Symbol: Tg(GFAP-APOE_i4)1Vln
• Name: transgene insertion 1, Fred Van Leuven
• MGI ID: MGI:3768431
• Synonyms: gae-1, Tg(GFAP-APOE*4)1Vln
• Transgene: Tg(GFAP-APOE_i4)1Vln Location: unknown
• Alliance: Tg(GFAP-APOE_i4)1Vln page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP-APOE_i4)1Vln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

• Mutation details: The transgenic construct contains a GFAP promoter used to drive the expression of a cDNA encoding the human wild-type amyloid precursor protein (695 isoform). In this transgenic mouse line, human APP protein is expressed in astroglia. Another line, line gae-III (GFAP-ApoE4 line 3) was also established. (J:128837)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128837 Tesseur I, et al., Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am J Pathol. 2000 Mar;156(3):951-64
• All: 2 reference(s)