Nanos2^tm3Ysa
Targeted Allele Detail

Summary

• Symbol: Nanos2^tm3Ysa
• Name: nanos C2HC-type zinc finger 2; targeted mutation 3, Yumiko Saga
• MGI ID: MGI:3768177
• Synonyms: nanos2^pA
• Gene: Nanos2 Location: Chr7:18721449-18722887 bp, + strand Genetic Position: Chr7, 9.45 cM
• Alliance: Nanos2^tm3Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119032
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous 3' untranslated region was replaced with a bovine growth hormone poly(A) signal. A floxed neo cassette was also inserted downstream of the poly(A) signal but was subsequently removed by cre-mediated recombination. RT-PCR analysis was used to confirm the presence of the modified transcript. (J:119032)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nanos2 Mutation: 15 strains or lines available

References

• Original: J:119032 Tsuda M, et al., Implication of nanos2-3'UTR in the expression and function of nanos2. Mech Dev. 2006 Jun;123(6):440-9
• All: 1 reference(s)