Tg(APOE_i3*)1Lmh
Transgene Detail

Summary

• Symbol: Tg(APOE_i3*)1Lmh
• Name: transgene insertion 1, Louis M Havekes
• MGI ID: MGI:3768079
• Synonyms: APOE*3Leiden, APOE*3Leiden-HCR, Tg(APOE*3)1Lmh
• Transgene: Tg(APOE_i3*)1Lmh Location: unknown
• Alliance: Tg(APOE_i3*)1Lmh page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE_i3*)1Lmh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

• Mutation details: A construct carrying a genomic fragment containing the human APOE*3 gene and endogenous promoter, and the intergenic region between APOCl and the APOCl pseudogene, harboring the postulated liver regulatory element (HCR, hepatic control region), was used to create transgenic mice. The human APOE*3-Leiden mutation is characterized by a tandem duplication of codons 120-126 and yields a mature protein of 306 amino acid residues. Northern blotting analysis indicates that this transgene is expressed in the liver. (J:128838)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128838 Jong MC, et al., Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1. Arterioscler Thromb Vasc Biol. 1996 Aug;16(8):934-40
• All: 8 reference(s)