Tg(Rgs4-EGFP)4Lvt
Transgene Detail

Summary

• Symbol: Tg(Rgs4-EGFP)4Lvt
• Name: transgene insertion 4, Pat Levitt
• MGI ID: MGI:3767843
• Synonyms: R4BAC4, RGS4-BAC, RGS4-BAC line 4, RGS4 BAC transgenic, RGS4-GFP, RGS4 transgenic
• Transgene: Tg(Rgs4-EGFP)4Lvt Location: unknown
• Alliance: Tg(Rgs4-EGFP)4Lvt page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F1

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: A C57BL/6J-derived bacterial artificial chromosome (BAC; RPCI-23-82i24) was modified by inserting an IRES2-eGFP construct (and an frt-flanked neomycin resistance cassette) into the 3' UTR of the Rgs4 locus. The neomycin cassette was subsequently removed by FLP-mediated recombination. Lines 3 and 4 were developed, and line 4 was entered as the representative transgenic allele. Under the control of the RGS4 promoter/enhancer elements, transgene expression reports dynamic developmental, regional, and cellular specific expression in developing and mature cerebral cortex neurons across all cortical domains, as well as developing and mature subcortical regions (telencephalon, diencephalon, and brainstem). (J:128689)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:128689 Ebert PJ, et al., Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during development. I. Cerebral cortex. Neuroscience. 2006 Nov 3;142(4):1145-61
• All: 3 reference(s)