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Tg(tetO-DTA)1Gfi
Transgene Detail
Nomenclature
Symbol: Tg(tetO-DTA)1Gfi
Name: transgene insertion 1, Glenn I Fishman
MGI ID: MGI:3767624
Synonyms: tet-DTA, tetODTA/+, tetO-DTA
Transgene: Tg(tetO-DTA)1Gfi  Location: unknown  
Cardiac fibrosis and ventricle dilatation in Tg(Myh6-tTA)6Smbf/0 Tg(tetO-DTA)1Gfi/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Mutation detailsA transgenic construct was created, containing diphtheria toxin A sequence (DTA) under the control of heptamerized tetracycline operator, tetO sequences fused to a cytomegalovirus minimal promoter. (J:128617)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: Narcolepsy J:211045, J:211046
References
Original:  J:128617 Lee P, et al., Conditional lineage ablation to model human diseases. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11371-6
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory