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Targeted Allele Detail
Symbol: Rapgef4tm1.1Sse
Name: Rap guanine nucleotide exchange factor (GEF) 4; targeted mutation 1.1, Susumu Seino
MGI ID: MGI:3767602
Synonyms: Epac2ko
Gene: Rapgef4  Location: Chr2:71981240-72257474 bp, + strand  Genetic Position: Chr2, 42.9 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:128493
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted into exon 1 and a floxed neo cassette was inserted downstream of exon 1. Cre-mediated recombination was used to delete a portion of exon 1. The absence of protein product in pancreatic islet cells was confirmed by RT-PCR analysis. (J:128493)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rapgef4 Mutation:  30 strains or lines available
Original:  J:128493 Shibasaki T, et al., Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19333-8
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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