About   Help   FAQ
Rapgef4tm1.1Sse
Targeted Allele Detail
Nomenclature
Symbol: Rapgef4tm1.1Sse
Name: Rap guanine nucleotide exchange factor (GEF) 4; targeted mutation 1.1, Susumu Seino
MGI ID: MGI:3767602
Synonyms: Epac2ko
Gene: Rapgef4  Location: Chr2:71981240-72257474 bp, + strand  Genetic Position: Chr2, 42.9 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128493
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into exon 1 and a floxed neo cassette was inserted downstream of exon 1. Cre-mediated recombination was used to delete a portion of exon 1. The absence of protein product in pancreatic islet cells was confirmed by RT-PCR analysis. (J:128493)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rapgef4 Mutation:  27 strains or lines available
References
Original:  J:128493 Shibasaki T, et al., Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19333-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/13/2017
MGI 6.10
The Jackson Laboratory