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Chemically induced Allele Detail
Symbol: Tlr9M2Btlr
Name: toll-like receptor 9; mutation 2, Bruce Beutler
MGI ID: MGI:3767565
Synonyms: CpG2, Tlr9CpG2, unmethylated CpG-oligodeoxynucleotide unresponsive 2
Gene: Tlr9  Location: Chr9:106099797-106104075 bp, + strand  Genetic Position: Chr9, 57.46 cM
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThe Cpg2 phenotype was identified in an ENU mutagenesis screen for mutants with impaired response to Toll-like receptor (TLR) ligands. The mutation is an A-to-T transversion at nucleotide position 3060 of the gene (Genbank Accession NM_031178) that results replacement of glutamine by leucine at amino acid position 985 of the receptor protein. (J:128405)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr9 Mutation:  49 strains or lines available
Original:  J:128405 Xiao N, et al., A second ENU-induced point mutation of Tlr9 specifically ablates immune response to oligodeoxynucleotides containing unmethylated CpG motifs. MGI Direct Data Submission. 2007;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.20
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